Roberto Chiarle Selected Research

Anaplastic Lymphoma Kinase

1/2022	Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma.
10/2020	High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells.
10/2020	IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
12/2018	Comment on "ALK is a therapeutic target for lethal sepsis".
2/2018	Tumor Resistance against ALK Targeted Therapy-Where It Comes From and Where It Goes.
11/2017	Epitope mapping of spontaneous autoantibodies to anaplastic lymphoma kinase (ALK) in non-small cell lung cancer.
5/2016	Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1.
3/2016	Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
1/2016	Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency.
12/2015	Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.

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Roberto Chiarle Research Topics

Disease

48	Neoplasms (Cancer) 12/2021 - 04/2002
23	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2022 - 02/2002
23	Lymphoma (Lymphomas) 01/2022 - 04/2002
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 12/2012
7	Genetic Translocation (Chromosomal Translocation) 12/2021 - 06/2005
6	Carcinogenesis 10/2017 - 02/2004
5	T-Cell Lymphoma (Lymphoma, T Cell) 01/2019 - 03/2003
4	Breast Neoplasms (Breast Cancer) 03/2017 - 10/2003
4	Neuroblastoma 01/2015 - 06/2011
4	Carcinoma (Carcinomatosis) 01/2015 - 11/2009
4	Pancreatic Neoplasms (Pancreatic Cancer) 09/2013 - 08/2009
4	Adenocarcinoma 05/2013 - 10/2007
3	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2022 - 04/2002
3	Lung Neoplasms (Lung Cancer) 02/2016 - 12/2011
3	Inflammation (Inflammations) 01/2014 - 10/2003
2	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2022 - 04/2015
2	B-Cell Lymphoma (Lymphoma, B Cell) 12/2021 - 06/2005
2	Adenocarcinoma of Lung 01/2020 - 10/2017
2	Neoplasm Metastasis (Metastasis) 04/2015 - 02/2010
1	Anemia 01/2022
1	COVID-19 01/2021
1	Neoplastic Cell Transformation 01/2021
1	Fibrosarcoma 10/2020
1	Bites and Stings (Sting) 12/2018
1	Lymphopenia (Lymphocytopenia) 10/2017
1	Disease Progression 01/2017
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2017
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/2017
1	Genomic Instability 01/2017

Drug/Important Bio-Agent (IBA)

31	Anaplastic Lymphoma KinaseIBA 01/2022 - 02/2002
17	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2002
6	AntigensIBA 10/2017 - 10/2007
6	DNA (Deoxyribonucleic Acid)IBA 05/2013 - 02/2004
5	Tyrosine (L-Tyrosine)FDA Link 01/2022 - 09/2005
5	Small Interfering RNA (siRNA)IBA 10/2020 - 05/2005
5	Phosphotransferases (Kinase)IBA 10/2017 - 01/2008
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2009 - 02/2002
4	CrizotinibIBA 10/2020 - 12/2012
4	Protein Isoforms (Isoforms)IBA 10/2017 - 11/2009
4	AntibodiesIBA 02/2016 - 05/2007
3	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 11/2009
3	MicroRNAs (MicroRNA)IBA 10/2020 - 04/2015
3	NucleophosminIBA 10/2020 - 12/2006
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 10/2017
3	AutoantibodiesIBA 11/2017 - 10/2007
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2011 - 04/2008
2	ras ProteinsIBA 01/2022 - 01/2019
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 02/2004
2	Ligases (Synthetase)IBA 12/2021 - 03/2007
2	UbiquitinIBA 12/2021 - 03/2007
2	RNA (Ribonucleic Acid)IBA 10/2020 - 03/2017
2	ParaffinIBA 01/2020 - 03/2017
2	Formaldehyde (Formol)FDA Link 01/2020 - 03/2017
2	GTP Phosphohydrolases (GTPases)IBA 01/2019 - 03/2016
2	Tyrosine Kinase InhibitorsIBA 02/2018 - 12/2015
2	Biological ProductsIBA 01/2018 - 10/2016
2	EnzymesIBA 11/2017 - 05/2013
2	Estrogen Receptor alphaIBA 03/2017 - 10/2003
2	Biomarkers (Surrogate Marker)IBA 03/2017 - 01/2014
2	Estrogen ReceptorsIBA 03/2017 - 10/2003
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 03/2016 - 04/2008
2	Pyridinolcarbamate (P23)IBA 01/2016 - 05/2007
2	VaccinesIBA 12/2015 - 05/2013
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2014 - 02/2010
2	Immunoglobulin G (IgG)IBA 05/2013 - 10/2007
2	Complement System Proteins (Complement)IBA 05/2013 - 04/2013
2	Phosphopyruvate Hydratase (Enolase)IBA 05/2013 - 08/2009
2	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2012 - 04/2009
2	Messenger RNA (mRNA)IBA 04/2008 - 03/2007
1	GATA1 Transcription FactorIBA 01/2022
1	5' Untranslated Regions (5' UTR)IBA 01/2022
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2021
1	Interleukin-17 (Interleukin 17)IBA 01/2021
1	CytokinesIBA 01/2021
1	ChemokinesIBA 01/2021
1	lenzilumabIBA 01/2021
1	VemurafenibIBA 10/2020
1	Interleukin-10 ReceptorsIBA 10/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	Mitogen-Activated Protein KinasesIBA 01/2019
1	Therapeutic UsesIBA 01/2019
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2019
1	Wiskott-Aldrich Syndrome ProteinIBA 01/2019
1	Guanosine Triphosphate (GTP)IBA 01/2019
1	InterferonsIBA 12/2018
1	ImmunosorbentsIBA 11/2017
1	Peptides (Polypeptides)IBA 11/2017
1	EpitopesIBA 11/2017
1	MitogensIBA 10/2017
1	Proto-Oncogene Proteins B-rafIBA 10/2017
1	ErbB Receptors (EGF Receptor)IBA 03/2017
1	Pharmaceutical PreparationsIBA 03/2017
1	idelalisibIBA 01/2017
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2017
1	duvelisibIBA 01/2017

Therapy/Procedure

16	Therapeutics 01/2021 - 10/2007
3	Drug Therapy (Chemotherapy) 11/2009 - 06/2008
2	Immunotherapy 01/2020 - 02/2016
1	Hematopoietic Stem Cell Transplantation 10/2017